Therapeutics Based on Stop Codon Readthrough
نویسندگان
چکیده
منابع مشابه
Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
Recent analysis of genomic signatures in mammals, flies, and worms indicates that functional translational stop codon readthrough is considerably more abundant in metazoa than previously recognized, but this analysis provides only limited clues about the function or mechanism of readthrough. If an mRNA known to be read through in one species is also read through in another, perhaps these questi...
متن کاملEvolutionary Dynamics of Abundant Stop Codon Readthrough
Translational stop codon readthrough emerged as a major regulatory mechanism affecting hundreds of genes in animal genomes, based on recent comparative genomics and ribosomal profiling evidence, but its evolutionary properties remain unknown. Here, we leverage comparative genomic evidence across 21 Anopheles mosquitoes to systematically annotate readthrough genes in the malaria vector Anopheles...
متن کاملPolypeptide chain termination and stop codon readthrough on eukaryotic ribosomes.
During protein translation, a variety of quality control checks ensure that the resulting polypeptides deviate minimally from their genetic encoding template. Translational fidelity is central in order to preserve the function and integrity of each cell. Correct termination is an important aspect of translational fidelity, and a multitude of mechanisms and players participate in this exquisitel...
متن کاملComputational Analysis of Stop Codon Readthrough in D.melanogaster
MOTIVATION Readthrough is an unusual process in which a stop codon is misread or skipped. Recently it has been shown that some translation is regulated by the readthrough reactions although the complete mechanism is not clear. Therefore, the discovery of 'readthrough genes' is important for further investigation of their cellular roles, which may provide additional insights into the mechanism o...
متن کاملTranslation initiation factor eIF3 promotes programmed stop codon readthrough
Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins. During this process, the stop codon is decoded as a sense codon by a near-cognate tRNA, which programs the ribosome to continue elongation. The efficiency of competition for the stop codon between release factors (eRFs) a...
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ژورنال
عنوان ژورنال: Annual Review of Genomics and Human Genetics
سال: 2014
ISSN: 1527-8204,1545-293X
DOI: 10.1146/annurev-genom-091212-153527